Analysis of Tyler's adenine base editing (ABE) screen targeting start and stop codons.
Raw screen outputs live in start_stop_ABE_screen_data/ (git-ignored):
| File | Level | Contents |
|---|---|---|
start_guide_summary.csv |
guide | Per-guide LFC, p-values, FDR, sensor editing efficiency (start codons) |
start_codon_summary.csv |
site | Annotated vs. non-canonical start site pairs, MAGeCK RRA scores |
stop_guide_summary.csv |
guide | Per-guide LFC, p-values, FDR, sensor editing efficiency (stop codons) |
stop_codon_summary.csv |
site | Stop site RRA scores with ClinVar annotations |
conda activate be-screen
uv pip install -e ".[dev]"ruff format src/ && ruff check src/
pytest