Code for corresponding manuscript. Link to manuscript here.
First, start with the "PUBLIC-lettuce_mutants_data_processing.ipynb" notebook to process the data into a usable format. Then use the "PUBLIC_tSNE_PCA_analysis.ipynb" notebook to complete the GMM, PCA, and tSNE analysis. Then use the "PUBLIC_Mutant_heatmap.ipynb" notebook to plot the heatmap. Then use the "Binding_model_lettuce.ipynb" notebook to solve the ODEs for the kinetic and dose response binding model from collected experimental data.
Each notebook starts with importing all the necessary packages. Please install anything that is missing before starting.
Each notebook starts with a different data file that is from the previous notebook. Each data file is linked with the manuscript.