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Levels: equal exposure per mg hormone for Basic esters; telmisartan at the 40 mg arm (presets-2026-10d) - #20
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…t the 40 mg arm (presets-2026-10d)
# Conflicts: # docs/MODELS.md
ApolloF
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October 11, 2026 22:47
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Why
A release audit (#19) found two level-model problems. Analysis:
1. Basic model exposure grows with half-life. The sheet's Basic peak (14·M·F·0.875) doesn't depend on t½, so one dose's area under the curve is ∝ t½ (AUC/F = 20.71·M·t½). Per mg of hormone, Tren E showed 7.3× Tren A's exposure, Parabolan 5.3×, Masteron E 2.25× Masteron P, Test Dec 1.9× the study-based testosterone esters. The ester only sets the release rate, so the same mg of hormone should give the same exposure.
2. Telmisartan Cmax is the average of a nonlinear pair. The sheet's 7.70 ng/mL per mg = mean per mg of the two arms of PMID 17009837 (40 mg: 163.2 ng/mL, 80 mg: 905.7 ng/mL; supraproportional per label). Linear use gave 1.9× too high at 40 mg (308 vs 163 ng/mL).
Also checked: retatrutide's sheet values are the exact means of the six Coskun 2022 (Cell Metab, Table 1) arms (Cmax 114.95 ng/mL per mg, t½ 147 h, Tmax 40 h); tirzepatide = 874 ng/mL at 15 mg, t½ 116.7 h. No change.
What
SheetRow.exposureAnchors: Basic esters anchored to their hormone's reference: Test PP/Iso/Dec → mean of Test E/C/P; Tren E, Parabolan → Tren A; Masteron E → Masteron P. Peak set so AUC per mg hormone equals the anchors' mean; t½, Tmax, rise unchanged. Test Iso's 0.6 multiplier is replaced. Not anchored: Tren A, Masteron P (family anchors), Primobolan Depot, DHB, estradiol valerate (sheet-calibrated multipliers), MENT, orals, SARMs.Presets.VERSION→ presets-2026-10d.PresetMigrationupgrades log snapshots / edited presets holding the exact v0.6.0 (-10c) kinetics of the 7 changed presets (checked against a real v0.6.0 backup).Tests
BasicExposureTest: equal exposure per mg hormone (closed form 1e-9 and numeric integration 0.5 %), ratios ≈ 1, unanchored rows keep the plain peak, anchors same hormone.PresetMigrationTest: 10c → 10d for Tren E, Test Dec, telmisartan (exact v0.6.0 values); edited copies stay.PresetsTest: telmisartan 40 mg peaks at 163.2 ng/mL.PkSheetGoldenTest: Tren E and Test Iso references scaled by exact peak ratio (3/22, 1.5426172); others unchanged../gradlew :core:domain:testpasses locally. No app/ or resource changes.Note for release notes
A user who set Adjust level on Trenbolone or Drostanolone to tame the old curve will now see it applied on top of the lower curve.