diff --git a/crates/io/src/mass_spec.rs b/crates/io/src/mass_spec.rs
index ed8ca44..3ec6507 100644
--- a/crates/io/src/mass_spec.rs
+++ b/crates/io/src/mass_spec.rs
@@ -141,6 +141,86 @@ pub struct ChromatogramChannel {
     pub values: Vec<f64>,
 }
 
+/// One programmed composition in a liquid-chromatography gradient method.
+#[derive(Debug, Clone, PartialEq, Serialize, Deserialize)]
+pub struct LcGradientPoint {
+    pub time_min: f64,
+    pub flow_ml_min: f64,
+    pub percent_b: f64,
+}
+
+/// The method information needed to relate a chromatographic retention time to
+/// the programmed mobile-phase composition.
+#[derive(Debug, Clone, PartialEq, Serialize, Deserialize)]
+pub struct LiquidChromatographyMethod {
+    pub name: Option<String>,
+    pub run_time_min: f64,
+    pub solvent_a: Option<String>,
+    pub solvent_b: Option<String>,
+    pub gradient: Vec<LcGradientPoint>,
+    pub detector_wavelengths_nm: Vec<f64>,
+    pub column: Option<String>,
+}
+
+impl LiquidChromatographyMethod {
+    pub fn validate(&self) -> Result<(), String> {
+        if !self.run_time_min.is_finite() || self.run_time_min <= 0.0 {
+            return Err("LC method has an invalid run time".to_owned());
+        }
+        if self.gradient.len() < 2 {
+            return Err("LC method needs at least two gradient points".to_owned());
+        }
+        let mut previous = f64::NEG_INFINITY;
+        for point in &self.gradient {
+            if !point.time_min.is_finite()
+                || point.time_min < 0.0
+                || point.time_min <= previous
+                || !point.flow_ml_min.is_finite()
+                || point.flow_ml_min <= 0.0
+                || !point.percent_b.is_finite()
+                || !(0.0..=100.0).contains(&point.percent_b)
+            {
+                return Err("LC method has an invalid gradient point".to_owned());
+            }
+            previous = point.time_min;
+        }
+        if self
+            .gradient
+            .last()
+            .is_some_and(|point| point.time_min > self.run_time_min)
+        {
+            return Err("LC method gradient extends past its run time".to_owned());
+        }
+        if self
+            .detector_wavelengths_nm
+            .iter()
+            .any(|value| !value.is_finite() || *value <= 0.0)
+        {
+            return Err("LC method has an invalid detector wavelength".to_owned());
+        }
+        Ok(())
+    }
+
+    /// Linearly interpolate the programmed B composition between time points.
+    pub fn percent_b_at(&self, time_min: f64) -> Option<f64> {
+        if !time_min.is_finite() || time_min < 0.0 {
+            return None;
+        }
+        let first = self.gradient.first()?;
+        if time_min <= first.time_min {
+            return Some(first.percent_b);
+        }
+        for pair in self.gradient.windows(2) {
+            let [left, right] = pair else { continue };
+            if time_min <= right.time_min {
+                let fraction = (time_min - left.time_min) / (right.time_min - left.time_min);
+                return Some(left.percent_b + fraction * (right.percent_b - left.percent_b));
+            }
+        }
+        self.gradient.last().map(|point| point.percent_b)
+    }
+}
+
 #[derive(Debug, Clone, Serialize, Deserialize)]
 pub struct MassSpecRun {
     pub source: String,
diff --git a/crates/io/src/waters.rs b/crates/io/src/waters.rs
index 57ff0fc..987de3b 100644
--- a/crates/io/src/waters.rs
+++ b/crates/io/src/waters.rs
@@ -11,6 +11,8 @@ use std::path::{Path, PathBuf};
 
 mod chromatograms;
 use chromatograms::parse_auxiliary_channels;
+mod inlet;
+pub use inlet::load as load_inlet_method;
 mod metadata;
 use metadata::{
     FunctionRecord, classify_function, parse_function_table, parse_header, parse_polarities,
@@ -702,10 +704,16 @@ fn unsupported(id: AcquisitionStreamId, layout: &Layout, instrument: Option<&str
 }
 
 fn provenance(bundle: &Bundle) -> Provenance {
-    let mut parameter_paths = ["_header.txt", "_functns.inf", "_extern.inf", "_chroms.inf"]
-        .into_iter()
-        .filter_map(|name| bundle.file(name).cloned())
-        .collect::<Vec<_>>();
+    let mut parameter_paths = [
+        "_header.txt",
+        "_functns.inf",
+        "_extern.inf",
+        "_chroms.inf",
+        "_inlet.inf",
+    ]
+    .into_iter()
+    .filter_map(|name| bundle.file(name).cloned())
+    .collect::<Vec<_>>();
     parameter_paths.sort();
     let mut companion_paths = bundle
         .functions
diff --git a/crates/io/src/waters/inlet.rs b/crates/io/src/waters/inlet.rs
new file mode 100644
index 0000000..3e0895b
--- /dev/null
+++ b/crates/io/src/waters/inlet.rs
@@ -0,0 +1,161 @@
+use super::*;
+use crate::{LcGradientPoint, LiquidChromatographyMethod};
+
+/// Read the human-readable inlet method embedded in a MassLynx RAW bundle.
+/// A missing method is distinct from a malformed method because callers can
+/// supply an explicit method for otherwise valid LC–MS data.
+pub fn load(path: &Path) -> Result<Option<LiquidChromatographyMethod>, IoError> {
+    let bundle = Bundle::discover(path)?;
+    let Some(path) = bundle.file("_inlet.inf") else {
+        return Ok(None);
+    };
+    parse(&std::fs::read(path)?).map(Some)
+}
+
+pub(super) fn parse(bytes: &[u8]) -> Result<LiquidChromatographyMethod, IoError> {
+    let text = String::from_utf8_lossy(bytes);
+    let mut name = None;
+    let mut run_time_min = None;
+    let mut solvent_a = None;
+    let mut solvent_b = None;
+    let mut gradient = Vec::new();
+    let mut detector_wavelengths_nm = Vec::new();
+    let mut column = None;
+    let mut in_gradient = false;
+
+    for raw_line in text.lines() {
+        let line = raw_line.trim();
+        if let Some(value) = value_after(line, "Inlet Method File:") {
+            name = Some(clean(value));
+        } else if run_time_min.is_none()
+            && let Some(value) = value_after(line, "Run Time:")
+        {
+            run_time_min = first_number(value);
+        } else if let Some(value) = value_after(line, "Solvent Name A:") {
+            solvent_a = Some(clean(value));
+        } else if let Some(value) = value_after(line, "Solvent Name B:") {
+            solvent_b = Some(clean(value));
+        } else if line.eq_ignore_ascii_case("[Gradient Table]") {
+            in_gradient = true;
+        } else if in_gradient && line.starts_with("Run Events:") {
+            in_gradient = false;
+        } else if in_gradient {
+            if let Some(point) = gradient_point(line)? {
+                gradient.push(point);
+            }
+        } else if let Some(value) = value_after(line, "Wavelength:")
+            && let Some(wavelength) = first_number(value)
+        {
+            detector_wavelengths_nm.push(wavelength);
+        } else if let Some(value) = value_after(line, "Column Type:") {
+            column = Some(clean(value));
+        }
+    }
+
+    detector_wavelengths_nm.sort_by(f64::total_cmp);
+    detector_wavelengths_nm.dedup_by(|left, right| left.total_cmp(right).is_eq());
+    let method = LiquidChromatographyMethod {
+        name,
+        run_time_min: run_time_min.ok_or_else(|| invalid("_INLET.INF has no pump run time"))?,
+        solvent_a,
+        solvent_b,
+        gradient,
+        detector_wavelengths_nm,
+        column,
+    };
+    method.validate().map_err(invalid)?;
+    Ok(method)
+}
+
+fn gradient_point(line: &str) -> Result<Option<LcGradientPoint>, IoError> {
+    let mut tokens = line.split_whitespace();
+    let Some(index) = tokens.next() else {
+        return Ok(None);
+    };
+    if !index.ends_with('.')
+        || !index[..index.len() - 1]
+            .bytes()
+            .all(|byte| byte.is_ascii_digit())
+    {
+        return Ok(None);
+    }
+    let values = tokens.collect::<Vec<_>>();
+    let (time, flow, percent_b) = if values
+        .first()
+        .is_some_and(|value| value.eq_ignore_ascii_case("Initial"))
+    {
+        (
+            0.0,
+            parse_number(values.get(1), "initial flow rate")?,
+            parse_number(values.get(3), "initial %B")?,
+        )
+    } else {
+        (
+            parse_number(values.first(), "gradient time")?,
+            parse_number(values.get(1), "gradient flow rate")?,
+            parse_number(values.get(3), "gradient %B")?,
+        )
+    };
+    Ok(Some(LcGradientPoint {
+        time_min: time,
+        flow_ml_min: flow,
+        percent_b,
+    }))
+}
+
+fn parse_number(value: Option<&&str>, label: &str) -> Result<f64, IoError> {
+    value
+        .and_then(|value| value.parse().ok())
+        .filter(|value: &f64| value.is_finite())
+        .ok_or_else(|| invalid(format!("_INLET.INF has invalid {label}")))
+}
+
+fn first_number(value: &str) -> Option<f64> {
+    value
+        .split_whitespace()
+        .find_map(|token| token.parse::<f64>().ok())
+        .filter(|value| value.is_finite())
+}
+
+fn value_after<'a>(line: &'a str, label: &str) -> Option<&'a str> {
+    line.get(..label.len())
+        .filter(|prefix| prefix.eq_ignore_ascii_case(label))
+        .map(|_| line[label.len()..].trim())
+        .filter(|value| !value.is_empty())
+}
+
+fn clean(value: &str) -> String {
+    value.replace('\u{fffd}', "").trim().to_owned()
+}
+
+#[cfg(test)]
+mod tests {
+    use super::*;
+
+    #[test]
+    fn parses_acquity_gradient_and_detector_details() {
+        let method = parse(
+            br#"Inlet Method File: d:\methods\5-95
+-- PUMP --
+ Run Time: 10.00 min
+ Solvent Name A: Water + acid
+ Solvent Name B: Acetonitrile + acid
+ [Gradient Table]
+  Time(min) Flow Rate %A %B Curve
+ 1. Initial 0.300 95.0 5.0 Initial
+ 2. 6.00 0.300 5.0 95.0 6
+ 3. 8.00 0.300 5.0 95.0 1
+ 4. 10.00 0.300 95.0 5.0 1
+ Run Events: Yes
+ Wavelength: 214 nm
+ Wavelength: 254 nm
+ Column Type: ACQUITY Protein BEH C4
+"#,
+        )
+        .unwrap();
+        assert_eq!(method.gradient.len(), 4);
+        assert_eq!(method.percent_b_at(3.0), Some(50.0));
+        assert_eq!(method.detector_wavelengths_nm, [214.0, 254.0]);
+        assert_eq!(method.column.as_deref(), Some("ACQUITY Protein BEH C4"));
+    }
+}