diff --git a/packages/cloudflare/src/instrumentations/instrumentSqlStorage.ts b/packages/cloudflare/src/instrumentations/instrumentSqlStorage.ts
index 96950dbb4f9e..adcf7c689bc1 100644
--- a/packages/cloudflare/src/instrumentations/instrumentSqlStorage.ts
+++ b/packages/cloudflare/src/instrumentations/instrumentSqlStorage.ts
@@ -5,6 +5,7 @@ import {
   SEMANTIC_ATTRIBUTE_SENTRY_ORIGIN,
   startSpan,
 } from '@sentry/core';
+import { targetsCloudflareInternalTable } from '../utils/internalSqlQuery';
 
 /**
  * Instruments the Durable Object SqlStorage `exec` method with Sentry spans.
@@ -23,9 +24,14 @@ export function instrumentSqlStorage(sql: SqlStorage): SqlStorage {
 
       return function (this: unknown, ...args: unknown[]) {
         const [query, ...bindings] = args as [string, ...unknown[]];
+
         const sanitizedQuery = _INTERNAL_sanitizeSqlQuery(query);
         const querySummary = _INTERNAL_getSqlQuerySummary(sanitizedQuery);
 
+        if (targetsCloudflareInternalTable(querySummary)) {
+          return (original as (...a: unknown[]) => ReturnType<SqlStorage['exec']>).apply(target, args);
+        }
+
         return startSpan(
           {
             op: 'db.query',
diff --git a/packages/cloudflare/src/utils/internalSqlQuery.ts b/packages/cloudflare/src/utils/internalSqlQuery.ts
new file mode 100644
index 000000000000..af3e7b5638f4
--- /dev/null
+++ b/packages/cloudflare/src/utils/internalSqlQuery.ts
@@ -0,0 +1,23 @@
+/**
+ * Cloudflare frameworks that build on Durable Objects (`agents`, `partyserver`, ...) manage their
+ * own internal SQLite tables, all namespaced with a `cf_` prefix — e.g. `cf_agents_schedules`,
+ * `cf_agent_state`, `cf_ai_chat_stream_chunks`. Queries against them (schedule polling, chat-stream
+ * persistence, state bookkeeping) are framework implementation details that otherwise flood traces
+ * with dozens of zero-signal `db.query` spans per request. The exact set of tables even varies
+ * between framework versions, so we match the reserved prefix rather than an enumerated list.
+ *
+ * User tables never use this prefix, so skipping their spans is safe.
+ *
+ * The check operates on the query summary produced by `getSqlQuerySummary` (`{operation} {table} ...`,
+ * the same value used as the span name), so table targets are already isolated from the rest of the
+ * query.
+ */
+export function targetsCloudflareInternalTable(querySummary: string | undefined): boolean {
+  if (!querySummary) {
+    return false;
+  }
+
+  const [, ...tables] = querySummary.split(' ');
+
+  return tables.some(table => table.toLowerCase().startsWith('cf_'));
+}
diff --git a/packages/cloudflare/test/instrumentSqlStorage.test.ts b/packages/cloudflare/test/instrumentSqlStorage.test.ts
index de5ba69f79b0..10b326cde981 100644
--- a/packages/cloudflare/test/instrumentSqlStorage.test.ts
+++ b/packages/cloudflare/test/instrumentSqlStorage.test.ts
@@ -144,6 +144,31 @@ describe('instrumentSqlStorage', () => {
     expect(startSpanSpy).toHaveBeenCalledTimes(2);
     expect(mockSql.exec).toHaveBeenCalledTimes(2);
   });
+
+  describe('internal storage queries', () => {
+    it('does not create a span for Cloudflare-internal queries', () => {
+      const startSpanSpy = vi.spyOn(sentryCore, 'startSpan');
+      const mockCursor = createMockCursor();
+      const mockSql = createMockSqlStorage(mockCursor);
+      const instrumented = instrumentSqlStorage(mockSql);
+
+      const result = instrumented.exec('SELECT * FROM cf_agents_state WHERE id = ?', 'foo');
+
+      expect(startSpanSpy).not.toHaveBeenCalled();
+      expect(mockSql.exec).toHaveBeenCalledWith('SELECT * FROM cf_agents_state WHERE id = ?', 'foo');
+      expect(result).toBe(mockCursor);
+    });
+
+    it('still creates a span for user queries', () => {
+      const startSpanSpy = vi.spyOn(sentryCore, 'startSpan');
+      const mockSql = createMockSqlStorage();
+      const instrumented = instrumentSqlStorage(mockSql);
+
+      instrumented.exec('SELECT * FROM users WHERE id = ?', 1);
+
+      expect(startSpanSpy).toHaveBeenCalledTimes(1);
+    });
+  });
 });
 
 function createMockCursor() {
diff --git a/packages/cloudflare/test/utils/internalSqlQuery.test.ts b/packages/cloudflare/test/utils/internalSqlQuery.test.ts
new file mode 100644
index 000000000000..4a57774a7824
--- /dev/null
+++ b/packages/cloudflare/test/utils/internalSqlQuery.test.ts
@@ -0,0 +1,75 @@
+import { _INTERNAL_getSqlQuerySummary } from '@sentry/core';
+import { describe, expect, it } from 'vitest';
+import { targetsCloudflareInternalTable } from '../../src/utils/internalSqlQuery';
+
+// Builds the summary the same way `instrumentSqlStorage` does, so the test exercises the real
+// operation -> summary -> detection path rather than hand-written summaries.
+const summarize = (query: string): string | undefined => _INTERNAL_getSqlQuerySummary(query);
+
+describe('targetsCloudflareInternalTable', () => {
+  describe('internal queries (cf_ tables)', () => {
+    it.each([
+      ['SELECT', 'SELECT * FROM cf_agents_state WHERE id = ?'],
+      ['INSERT', 'INSERT INTO cf_agents_fibers (id, callback) VALUES (?, ?)'],
+      ['DELETE', 'DELETE FROM cf_agents_schedules WHERE id = ?'],
+      ['UPDATE', 'UPDATE cf_agent_tool_runs SET output_json = ? WHERE id = ?'],
+      ['CREATE TABLE', 'CREATE TABLE IF NOT EXISTS cf_agents_workflows (id TEXT PRIMARY KEY NOT NULL)'],
+      ['ALTER TABLE', 'ALTER TABLE cf_agents_queues ADD COLUMN retry_options TEXT'],
+      ['DROP TABLE', 'DROP TABLE cf_agents_state'],
+      ['cf_agent_ prefix', 'SELECT * FROM cf_agent_identity'],
+      ['cf_ai_ prefix', 'INSERT INTO cf_ai_chat_stream_chunks (id) VALUES (?)'],
+      ['cf_mcp_ prefix', 'SELECT * FROM cf_mcp_agent_event'],
+      ['schema version', 'SELECT version FROM cf_schema_version'],
+    ])('returns true for %s on internal tables', (_label, query) => {
+      expect(targetsCloudflareInternalTable(summarize(query))).toBe(true);
+    });
+
+    it('returns true for an internal JOIN', () => {
+      const query = `
+        SELECT f.fiber_id, f.status
+        FROM cf_agents_fibers f
+        LEFT JOIN cf_agents_runs r ON r.id = f.fiber_id
+        WHERE f.status IN ('pending', 'running')
+      `;
+      expect(targetsCloudflareInternalTable(summarize(query))).toBe(true);
+    });
+
+    it('returns true when an internal table is joined with a user table', () => {
+      // `.some()` — any internal table present means the query is framework-driven noise.
+      expect(
+        targetsCloudflareInternalTable(summarize('SELECT * FROM cf_agents_state s JOIN users u ON u.id = s.id')),
+      ).toBe(true);
+    });
+
+    it('handles case-insensitive keywords and prefixes', () => {
+      expect(targetsCloudflareInternalTable(summarize('select * from CF_AGENTS_STATE'))).toBe(true);
+    });
+  });
+
+  describe('user queries (must be instrumented)', () => {
+    it.each([
+      ['SELECT', 'SELECT * FROM users WHERE id = ?'],
+      ['INSERT', 'INSERT INTO orders (id, total) VALUES (?, ?)'],
+      ['UPDATE', 'UPDATE products SET price = ? WHERE id = ?'],
+      ['DELETE', 'DELETE FROM sessions WHERE expired = 1'],
+      ['CREATE TABLE', 'CREATE TABLE users (id TEXT PRIMARY KEY)'],
+      ['table with cf in the middle', 'SELECT * FROM my_cf_table'],
+      ['table starting with cfg', 'SELECT * FROM cfg_settings'],
+    ])('returns false for %s on user tables', (_label, query) => {
+      expect(targetsCloudflareInternalTable(summarize(query))).toBe(false);
+    });
+  });
+
+  describe('summaries without a resolvable table target (safe default: instrument)', () => {
+    it.each([
+      ['undefined', undefined],
+      ['empty', ''],
+      ['no-table SELECT', 'SELECT 1'],
+      ['PRAGMA', 'PRAGMA foreign_keys = ON'],
+      ['bare operation', 'BEGIN'],
+    ])('returns false for %s', (_label, value) => {
+      const summary = typeof value === 'string' ? summarize(value) : value;
+      expect(targetsCloudflareInternalTable(summary)).toBe(false);
+    });
+  });
+});