diff --git a/ci/test/00_setup_env_native_asan.sh b/ci/test/00_setup_env_native_asan.sh
index c3029cfe68b4..909c42ece182 100755
--- a/ci/test/00_setup_env_native_asan.sh
+++ b/ci/test/00_setup_env_native_asan.sh
@@ -7,12 +7,12 @@
 export LC_ALL=C.UTF-8
 
 export CONTAINER_NAME=ci_native_asan
-export PACKAGES="clang-19 llvm-19 libclang-rt-19-dev python3-zmq qtbase5-dev qttools5-dev-tools libevent-dev bsdmainutils libboost-dev libdb5.3++-dev libminiupnpc-dev libzmq3-dev libqrencode-dev"
+export PACKAGES="clang-19 llvm-19 libclang-rt-19-dev python3-zmq qtbase5-dev qttools5-dev-tools libevent-dev bsdmainutils libboost-dev libminiupnpc-dev libzmq3-dev libqrencode-dev"
 # Reuses the depends built for the linux64 target, which uses the defaults.
 export DEP_OPTS=""
 export TEST_RUNNER_EXTRA="--timeout-factor=4 -j2"  # Increase timeout because sanitizers slow down
 export GOAL="install"
-export BITCOIN_CONFIG="--enable-zmq --enable-crash-hooks --with-gui=qt5 \
+export BITCOIN_CONFIG="--enable-zmq --enable-crash-hooks --with-gui=qt5 --without-bdb --with-sqlite \
 --with-sanitizers=address,float-divide-by-zero,integer,undefined \
 CPPFLAGS='-DARENA_DEBUG -DDEBUG_LOCKORDER' \
 CC='clang-19 -ftrivial-auto-var-init=pattern' CXX='clang++-19 -ftrivial-auto-var-init=pattern'"
diff --git a/test/sanitizer_suppressions/lsan b/test/sanitizer_suppressions/lsan
index fc1d82f45976..1f21de07afd5 100644
--- a/test/sanitizer_suppressions/lsan
+++ b/test/sanitizer_suppressions/lsan
@@ -1,4 +1,5 @@
 # Suppress warnings triggered in dependencies
 leak:libQt5Widgets
 leak:QDBusConnectionPrivate
+leak:QDBusConnectionManager
 leak:QLayoutPrivate